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Quizzes > Quizzes for Business > Healthcare

Pharmacology Knowledge Test: Erectile Dysfunction and BPH Drugs

Assess Your Knowledge of ED and BPH Drugs

Difficulty: Moderate
Questions: 20
Learning OutcomesStudy Material
Colorful paper art promoting a Pharmacology Knowledge Test on Erectile Dysfunction and BPH Drugs.

Ready to test your grasp of ED and BPH pharmacotherapy? This focused practice quiz is perfect for pharmacy students, nurses, and healthcare professionals seeking to sharpen their understanding of erectile dysfunction and BPH drugs. By tackling each multiple-choice question, you'll reinforce dosing principles, side effect profiles, and mechanism of action insights. Customize this Pharmacology Knowledge Quiz in our editor to match your learning needs, or explore more pharmacology review quizzes in our quizzes library. Take the next step toward pharmacology mastery today!

Which of the following is a phosphodiesterase type 5 inhibitor?
Terazosin
Finasteride
Sildenafil
Tamsulosin
Sildenafil is a selective phosphodiesterase type 5 inhibitor used to treat erectile dysfunction. The others are either alpha-1 blockers (tamsulosin, terazosin) or a 5α-reductase inhibitor (finasteride).
Which agent is an alpha-1 adrenergic blocker used in benign prostatic hyperplasia?
Finasteride
Alfuzosin
Avanafil
Dutasteride
Alfuzosin is an alpha-1 adrenergic antagonist that relaxes prostatic smooth muscle in BPH. Finasteride and dutasteride inhibit 5α-reductase, while avanafil is a PDE5 inhibitor.
Which drug is classified as a 5α-reductase inhibitor?
Dutasteride
Prazosin
Silodosin
Tadalafil
Dutasteride inhibits both type I and II 5α-reductase isoforms, reducing dihydrotestosterone production in BPH. Tadalafil is a PDE5 inhibitor; silodosin and prazosin are alpha-1 blockers.
What is the primary mechanism of action of PDE5 inhibitors in erectile dysfunction?
Block adenosine uptake
Increase cGMP by inhibiting its breakdown
Antagonize alpha-1 receptors
Increase cAMP levels
PDE5 inhibitors block degradation of cyclic guanosine monophosphate (cGMP), enhancing smooth muscle relaxation and penile erection. They do not directly affect cAMP or alpha receptors.
When should sildenafil typically be taken relative to sexual activity?
24 hours before sexual activity
One hour before sexual activity
Immediately after sexual activity
Once daily at bedtime
Sildenafil is most effective when taken approximately one hour before sexual activity. Taking it immediately after or far in advance does not align with its pharmacokinetic profile.
Which PDE5 inhibitor has the longest elimination half-life?
Vardenafil
Tadalafil
Avanafil
Sildenafil
Tadalafil has an elimination half-life of about 17.5 hours, much longer than sildenafil, vardenafil, or avanafil, which range from 4 - 6 hours. This grants tadalafil a longer duration of action.
How does a high-fat meal affect the absorption of sildenafil?
No significant effect on pharmacokinetics
Increases bioavailability with no delay
Speeds up onset and increases Cmax
Delays onset and reduces Cmax
A high-fat meal delays sildenafil's Tmax and reduces peak concentration (Cmax). Food does not increase bioavailability or have no effect; it delays absorption.
Which alpha-1 blocker is most selective for the prostatic alpha-1A receptor subtype?
Doxazosin
Tamsulosin
Terazosin
Prazosin
Tamsulosin selectively targets alpha-1A receptors predominant in prostatic tissue, reducing urinary symptoms with fewer vascular side effects than nonselective agents like terazosin, doxazosin, or prazosin.
Finasteride primarily inhibits which 5α-reductase isoform?
Type III
Type II
Both type I and II
Type I
Finasteride is selective for the type II 5α-reductase isoform, reducing dihydrotestosterone levels in the prostate. Dutasteride inhibits both type I and II isoforms.
Which of the following is a major contraindication for phosphodiesterase type 5 inhibitors?
Stable hypertension
Antihistamines
Concurrent nitrate therapy
Selective serotonin reuptake inhibitors
Combining PDE5 inhibitors with nitrates can cause severe hypotension due to synergistic vasodilation. SSRIs, antihistamines, or controlled hypertension are not absolute contraindications.
What is the most common cardiovascular side effect of alpha-1 adrenergic blockers?
Hypertension
Tachyarrhythmias
Orthostatic hypotension
Bradycardia
Alpha-1 blockers can cause vasodilation leading to orthostatic hypotension and dizziness. They are less commonly associated with arrhythmias or hypertension.
Which adverse effect is commonly associated with 5α-reductase inhibitors?
Headache
Gynecomastia
Priapism
Nasal congestion
5α-reductase inhibitors like finasteride and dutasteride can cause hormonal side effects including gynecomastia. Priapism is linked to PDE5 inhibitors, while headache or congestion are less specific.
Which drug interaction is most clinically significant for PDE5 inhibitors?
Concomitant beta-blocker use
Co-administration with erythromycin
Concurrent diuretic therapy
NSAID co-administration
Erythromycin and other strong CYP3A4 inhibitors can markedly increase PDE5 inhibitor concentrations, raising risk of adverse effects. Beta-blockers, diuretics, or NSAIDs have less impact on their metabolism.
Floppy iris syndrome during cataract surgery is most commonly associated with which BPH medication?
Dutasteride
Tamsulosin
Finasteride
Sildenafil
Tamsulosin and other alpha-1 antagonists can cause intraoperative floppy iris syndrome. 5α-reductase inhibitors and PDE5 inhibitors are not implicated in this effect.
Combining PDE5 inhibitors with alpha-1 blockers primarily risks which adverse effect?
Severe hypotension
Urinary retention
Flushing
Increased libido
Both PDE5 inhibitors and alpha-1 blockers lower blood pressure through vasodilation, and their combination can precipitate severe hypotension. Urinary retention or libido changes are not the main concern.
Dutasteride differs from finasteride by inhibiting which 5α-reductase isoforms?
Type III only
Both type I and II
Type II only
Type I only
Dutasteride nonselectively inhibits both type I and II 5α-reductase isoforms, reducing peripheral and prostatic dihydrotestosterone production. Finasteride is selective for type II.
In patients with significant hepatic impairment, which PDE5 inhibitor typically requires dose adjustment?
Avanafil
Sildenafil
Vardenafil
Tadalafil
Tadalafil undergoes extensive hepatic metabolism and its clearance is reduced in hepatic impairment, necessitating dose adjustment. Sildenafil, vardenafil, and avanafil also require caution but have less pronounced recommendations.
A patient receiving ketoconazole is prescribed tadalafil. What dose adjustment is recommended?
Reduce to 10 mg every 72 hours
No adjustment needed
Reduce to 5 mg once weekly
Increase to 40 mg daily
Strong CYP3A4 inhibitors like ketoconazole reduce tadalafil clearance, so dosing should be limited to 10 mg every 72 hours. No adjustment or increasing the dose would risk toxicity.
After one year of monotherapy for BPH, which agent demonstrates the greatest reduction in prostate volume?
Finasteride
Neither reduces volume
Tamsulosin
Both are equal
Finasteride reduces prostate volume by about 20 - 30% over one year by inhibiting dihydrotestosterone formation. Tamsulosin relieves symptoms by muscle relaxation without significant volume reduction.
Beyond erectile dysfunction, PDE5 inhibitors may improve lower urinary tract symptoms by which mechanism?
Blocking calcium channels in the urethra
Increasing cGMP to relax bladder neck smooth muscle
Enhancing beta-3 adrenergic activity
Inhibiting muscarinic receptors in the detrusor
PDE5 inhibitors increase cGMP in prostatic and bladder neck smooth muscle, promoting relaxation and improving urinary flow. They do not act via muscarinic blockade, calcium channel blockade, or beta-3 adrenergic pathways directly.
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Learning Outcomes

  1. Identify key pharmacodynamic and pharmacokinetic properties of PDE5 inhibitors
  2. Evaluate mechanisms of action for α1-blockers and 5α-reductase inhibitors
  3. Apply appropriate dosing strategies for erectile dysfunction medications
  4. Differentiate side effect profiles of ED and BPH treatments
  5. Analyze potential drug interactions affecting urinary function

Cheat Sheet

  1. Pharmacokinetics of PDE5 Inhibitors - Think of half-life as the engine runtime: sildenafil and vardenafil run for about 4 hours, while tadalafil keeps you cruising up to 17.5 hours. This difference lets you tailor therapy to your lifestyle - from spontaneous weekend plans to scheduled rendezvous. PMC article on PDE5 inhibitors
  2. Mechanism of Action of α1-Blockers - Imagine α1-blockers as the key that relaxes the smooth muscle "locks" in your bladder neck and prostate, turning on the floodgates for easier urine flow. By blocking α1-adrenergic receptors, these drugs give BPH patients a smooth sailing restroom experience. NCBI Bookshelf: α1-Blockers in BPH
  3. 5α-Reductase Inhibitors - Finasteride and dutasteride act like tiny landscapers, trimming down dihydrotestosterone (DHT) levels so your prostate doesn't overgrow its welcome. Over time, this "pruning" shrinks prostate volume and eases bothersome BPH symptoms. NCBI Bookshelf: 5α-Reductase Inhibitors
  4. Dosing Strategies - Flexibility is key: tadalafil's long half-life lets you take it daily or only when you plan ahead, while sildenafil and vardenafil are more like "pop-up" therapies you use just before sexual activity. Choose your dosing schedule based on spontaneity versus routine. Healthline: PDE5 inhibitors guide
  5. Side Effects to Watch - While PDE5 inhibitors can bring a few headaches, flushing episodes, or nasal congestion, α1-blockers might make you feel dizzy or lightheaded. And 5α-reductase inhibitors can occasionally cramp your style with sexual dysfunction - but most effects are mild and manageable. NCBI Bookshelf: Side effect profiles
  6. Drug Interactions Alert - Mixing α1-blockers with PDE5 inhibitors can turbocharge your blood pressure drop, so clinician caution is a must. Always review your full medication list to steer clear of unexpected hypotension. NCBI Bookshelf: Interactions
  7. Contraindications for PDE5 Inhibitors - If you're on nitrates, PDE5 inhibitors are a no-go, as the combination can lead to dangerously low blood pressure. Always check for nitrate therapy before prescribing. Healthline: Contraindications
  8. Onset of Action - For those who like quick results, sildenafil and vardenafil kick in within 30 - 60 minutes. Tadalafil plays a "slow burn" and can take up to 2 hours, so plan accordingly! PMC article on timing
  9. α1-Blocker Selectivity - Tamsulosin is like a sniper, homing in on α1A receptors in the prostate and bladder neck to reduce urinary symptoms without toppling your blood pressure. Non-selective blockers may hit α1B receptors too, increasing dizziness risk. Mayo Clinic Proceedings on tamsulosin
  10. Combination Therapy Benefits - Teamwork makes the dream work: pairing α1-blockers with 5α-reductase inhibitors often beats solo therapy in shrinking prostate size and squashing BPH symptoms. Think of it as a tag-team duo for maximum relief. PMC article on combo therapy
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