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Quizzes > Health & Medicine > Human Anatomy & Medicine

Free COMLEX Practice Test: Challenge Yourself Now

Ready for COMLEX Level 1 Practice Questions? Dive In!

Difficulty: Moderate
2-5mins
Learning OutcomesCheat Sheet
paper art for COMLEX practice test challenge yourself answer 50 osteopathic exam questions NBOME style on teal background

Ready to ace your osteopathic licensing journey? Dive into our free COMLEX practice test - 50 NBOME-style questions crafted to challenge your comlex level 1 practice questions knowledge, powered by realistic exam simulation, and highlight key focus areas for comlex exam prep. Track your progress, refine your approach with osteopathic physician exam practice insights, and boost confidence in your nbome comlex practice routine. When you're set for the next level, tackle our comlex level 3 practice test or expand your readiness with the NLE practice exam . Start now to sharpen your skills!

At what vertebral level does the trachea normally bifurcate into the main bronchi?
T3
T4
T5
T6
The trachea bifurcates at the level of the sternal angle, which corresponds anteriorly to T4 (and posteriorly to T5). This landmark, also known as the Angle of Louis, is critical for thoracic anatomy and imaging. Recognizing this level helps clinicians localize mediastinal structures. Radiopaedia
Which cranial nerve carries taste sensation from the anterior two-thirds of the tongue?
Glossopharyngeal nerve (IX)
Facial nerve (VII)
Trigeminal nerve (V)
Vagus nerve (X)
The facial nerve (VII) transmits taste fibers from the anterior two-thirds of the tongue via the chorda tympani branch. The glossopharyngeal nerve handles taste from the posterior third. The trigeminal nerve provides general sensation, not taste. NCBI Bookshelf
In osteopathic manipulative treatment, which technique applies force directly toward the restrictive barrier of a somatic dysfunction?
Direct technique
Indirect technique
Balanced ligamentous tension
Muscle energy
Direct techniques engage the restrictive barrier of a somatic dysfunction by moving the tissue into the tightest point. Indirect techniques move away from the barrier toward the position of ease. Balanced ligamentous tension treats ligaments at neutral. AOA OMT
Which muscle is the primary elevator of the mandible?
Masseter
Lateral pterygoid
Digastric
Orbicularis oris
The masseter muscle is the most powerful elevator of the mandible, allowing jaw closure with significant force. The lateral pterygoid primarily protrudes and depresses the mandible. The digastric assists with depression, and orbicularis oris controls lip movement, not mastication. TeachMeAnatomy
Deficiency of which vitamin leads to megaloblastic anemia and neurologic symptoms due to impaired myelin synthesis?
Vitamin B12
Folate (B9)
Vitamin B6
Vitamin C
Vitamin B12 is required for DNA synthesis and myelin formation. Its deficiency causes megaloblastic anemia and subacute combined degeneration of the spinal cord, leading to neurologic deficits. Folate deficiency causes megaloblastic anemia but without neurologic signs. NCBI Bookshelf
The primary mechanism of action of benzodiazepines is to:
Increase the frequency of chloride channel opening at GABA-A receptors
Increase the duration of chloride channel opening at GABA-A receptors
Block GABA-A receptor binding
Act as a GABA-B receptor agonist
Benzodiazepines enhance GABA-A receptor function by increasing the frequency of channel opening in response to GABA, producing anxiolytic and sedative effects. Barbiturates increase the duration of opening instead. They do not activate GABA-B receptors. Pharmacology Section
In the TART acronym used for diagnosing somatic dysfunction, what does the 'R' represent?
Restriction
Redness
Relaxation
Resistance
TART stands for Tenderness, Asymmetry, Restriction of motion, and Tissue texture changes. 'Restriction' refers to limited range of motion in the dysfunctional segment. This component helps direct appropriate osteopathic technique. AOA OMT
A deficiency of lipoprotein lipase most specifically leads to an accumulation of which lipoprotein in the bloodstream?
Chylomicrons
VLDL
LDL
HDL
Lipoprotein lipase hydrolyzes triglycerides in chylomicrons and VLDL into free fatty acids. Deficiency causes accumulation of chylomicrons, leading to high triglyceride levels. VLDL and LDL levels are affected differently. NCBI Bookshelf
Occlusion of the anterior cerebral artery typically results in which of the following clinical deficits?
Contralateral lower extremity weakness and sensory loss
Contralateral facial paralysis
Ipsilateral homonymous hemianopia
Ataxia and dysmetria
The anterior cerebral artery supplies the medial aspect of the cerebral hemispheres, including the paracentral lobule that controls the lower extremity. Occlusion leads to contralateral leg weakness and sensory loss. Facial areas are supplied by the middle cerebral artery. Stroke Pathophysiology
An arterial blood gas shows pH 7.25, PaCO2 60 mmHg, and HCO3– 26 mEq/L. What is the primary acid–base disturbance?
Respiratory acidosis
Metabolic acidosis
Mixed respiratory and metabolic acidosis
Metabolic alkalosis
A pH of 7.25 indicates acidemia. An elevated PaCO2 (60 mmHg) indicates hypoventilation and respiratory acidosis. The normal HCO3– suggests no primary metabolic disturbance. Compensation is not complete given the pH. Life in the Fast Lane
5-Fluorouracil exerts its anticancer effect primarily by inhibiting which enzyme?
Thymidylate synthase
Dihydrofolate reductase
Topoisomerase II
DNA polymerase
5-Fluorouracil is converted to FdUMP, which binds and irreversibly inhibits thymidylate synthase, blocking dTMP synthesis and DNA replication. It does not directly inhibit dihydrofolate reductase or topoisomerases. NCBI Pharm
In muscle energy technique, the patient engages in what action during the treatment?
Active isometric contraction against a counterforce
Relaxed passive stretch by physician
Rapid thrust at the restrictive barrier
Direct mobilization into the barrier
Muscle energy technique requires the patient to perform a controlled isometric contraction against the physician's counterforce, followed by relaxation and repositioning. This engages neuromuscular reflexes to improve range of motion. It differs from HVLA thrust or passive stretching. AOA OMT
A lesion affecting the dorsal column at the T6 level will produce which sensory deficit?
Loss of vibration and proprioception below T6
Loss of pain and temperature below T6
Loss of fine touch only at T6 dermatome
Ipsilateral motor weakness below T6
The dorsal columns transmit vibration and proprioceptive sensations. A lesion at T6 disconnects those pathways below that level, causing loss of those modalities. Pain and temperature run in the spinothalamic tracts, which are unaffected. NCBI Neuroscience
In Type II lumbar somatic dysfunction, the spinous process rotates in which direction relative to the vertebral body rotation?
Opposite the direction of vertebral body rotation
Same direction as vertebral body rotation
No rotation occurs
Rotation depends on side-bending
Type II dysfunctions involve rotation and side-bending in opposite directions, with the spinous process deviating opposite the direction of vertebral body rotation. This classic pattern distinguishes Type II from Type I. AOA OMT
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Study Outcomes

  1. Apply Osteopathic Principles -

    Use fundamental osteopathic concepts in clinical scenarios similar to those found in COMLEX practice test questions.

  2. Analyze NBOME-Style Questions -

    Break down and interpret COMLEX Level 1 practice questions designed in NBOME format to enhance reasoning skills.

  3. Identify Knowledge Gaps -

    Pinpoint your strengths and weaknesses across osteopathic physician exam practice to focus your study efforts.

  4. Manage Time Efficiently -

    Implement time-management techniques under timed conditions to mirror real COMLEX exam prep experiences.

  5. Utilize Targeted Exam Strategies -

    Apply proven approaches for answering questions accurately and boosting confidence in COMLEX exam prep.

  6. Integrate Feedback for Improved Learning -

    Leverage quiz results from the free comlex practice test to guide subsequent review sessions and study plans.

Cheat Sheet

  1. TART Mnemonic for Somatic Dysfunction -

    Use the TART framework (Tissue texture changes, Asymmetry, Restriction of motion, Tenderness) to systematically identify somatic dysfunction in your comlex practice test review. For example, note how increased tissue tension correlates with hypertonic muscles in lumbar somatic dysfunction. (Source: American Academy of Osteopathy)

  2. Fryette's Laws of Spinal Mechanics -

    Remember Law I (neutral mechanics in a group of vertebrae) versus Law II (non-neutral mechanics in a single vertebra), and use the phrase "neutral equals group, non-neutral equals single." For instance, a group curve in the thoracic spine rotates and sidebends to opposite sides when neutral. (Source: Foundations for Osteopathic Medicine)

  3. Primary Respiratory Mechanism (PRM) Basics -

    Master the five components of PRM: inherent motility of brain & spinal cord, CSF fluctuations, dural membrane tension, cranial bone mobility, and sacral motion. Picture the dura like a "bounce" that drives cranial rhythmic impulse at ~10 - 14 cycles per minute. (Source: U.S. Osteopathic Association)

  4. Henderson-Hasselbalch Equation in Acid-Base Disorders -

    Practice pH = pKa + log([HCO₃❻]/(0.03×pCO₂)) to predict metabolic versus respiratory disturbances on your comlex level 1 practice questions. A quick tip: "ROME" (Respiratory Opposite, Metabolic Equal) helps you remember pH - CO₂ and pH - HCO₃❻ relationships. (Source: Guyton & Hall Physiology)

  5. Fluid Compartment Calculations (60-40-20 Rule) -

    Apply the 60-40-20 rule: total body weight is ~60% water, 40% intracellular fluid, and 20% extracellular fluid (including plasma). For a 70 kg patient, that's 42 L TBW, 28 L ICF, and 14 L ECF - key for questions on fluid shifts or IV bolus dosing. (Source: Goodman & Gilman's Pharmacology)

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