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Quizzes > Science > Biology

Think You Know the Cell Cycle? Take the Quiz!

Dive into our mitosis & cytokinesis quiz - true or false and more!

Difficulty: Moderate
2-5mins
Learning OutcomesCheat Sheet
Paper art cell cycle icons for mitosis and cytokinesis with quiz formats on sky blue background

Ready to dive into the world of cellular division? Take our free cell cycle quiz to challenge and sharpen your knowledge of mitosis, cytokinesis, and the phases that keep life going. Want to put your critical thinking to the test with a cytokinesis true/false quiz or see how well you know each stage in a mitosis quiz? Start with our interactive cell cycle quiz and dive into engaging multiple-choice and true/false items. Perfect for students, instructors, and science enthusiasts, you'll get instant feedback and clear explanations to master each phase of the cycle. Ready to prove your expertise in cell division trivia ? Jump in now and see how you score!

Which of the following is the correct sequence of phases in the eukaryotic cell cycle?
M, G1, S, G2
S, G1, G2, M
G1, G2, S, M
G1, S, G2, M
The eukaryotic cell cycle progresses through G1 (first gap), S (DNA synthesis), G2 (second gap), and M (mitosis). This order ensures proper growth, DNA replication, and preparation for cell division. Each phase is tightly regulated by cyclin-CDK complexes to maintain genomic integrity. https://www.nature.com/scitable/topicpage/the-cell-cycle-an-overview-14046377/
During which phase of the cell cycle does DNA replication occur?
M phase
S phase
G2 phase
G1 phase
DNA replication occurs during the S (synthesis) phase of interphase, ensuring each daughter cell receives an identical genome. G1 is a growth phase, G2 prepares for mitosis, and M phase is when cell division occurs. Failure to duplicate DNA during S phase prevents progression into G2, highlighting its critical role. https://www.britannica.com/science/S-phase
True or False: Cytokinesis is the process of nuclear division.
False
True
Cytokinesis refers to the division of the cytoplasm, resulting in two separate daughter cells. Nuclear division is actually called mitosis. Cytokinesis occurs after mitosis to physically separate the two new nuclei. https://www.cellsignal.com/contents/science-high-school/mitosis-vs-meiosis/cytokinesis
What structure forms to separate chromosomes during anaphase of mitosis?
Nuclear envelope
Spindle fibers
Cell plate
Centromeres
During anaphase, spindle fibers attached to kinetochores pull sister chromatids apart toward opposite poles. These microtubule structures originate from centrosomes at opposite ends of the cell. This separation mechanism ensures accurate chromosome segregation. https://www.ncbi.nlm.nih.gov/books/NBK9841/
Which cell cycle checkpoint ensures DNA is replicated correctly before mitosis?
G1 checkpoint
Spindle checkpoint
G2 checkpoint
Metaphase checkpoint
The G2 checkpoint verifies that DNA replication is complete and checks for any DNA damage before allowing the cell to enter mitosis. This checkpoint prevents propagation of mutations by halting the cycle if errors are detected. Cell cycle checkpoints are vital for maintaining genomic stability. https://www.ncbi.nlm.nih.gov/books/NBK26896/
Which protein complex triggers the onset of anaphase by degrading securin?
Cyclin B
Anaphase-promoting complex/Cyclosome (APC/C)
MPF
Cohesin
The APC/C ubiquitinates securin, leading to its degradation and permitting separase to cleave cohesin rings. This triggers the separation of sister chromatids at anaphase. This process ensures that chromatids only separate after proper spindle attachment. https://www.nature.com/scitable/topicpage/the-anaphase-promoting-complex-a-key-498
In plant cells, cytokinesis involves the formation of which structure?
Cleavage furrow
Contractile ring
Cell wall
Cell plate
Plant cells build a cell plate at the center of the dividing cell from Golgi-derived vesicles. This cell plate ultimately becomes the new cell wall separating the daughter cells. It expands outward to fuse with the existing plasma membrane. https://www.britannica.com/science/cell-division
What is the role of p53 in cell cycle regulation?
Accelerates S phase
Promotes cyclin D production
Acts as a tumor suppressor, arresting cycle at G1/S
Initiates cytokinesis
p53 responds to DNA damage by activating transcription of p21, which inhibits cyclin-CDK complexes to arrest the cell cycle at the G1/S checkpoint. Mutation of p53 is one of the most common events in human cancers, underscoring its critical role. By halting progression, p53 prevents replication of damaged DNA. https://www.atsdr.cdc.gov/csem/csem.asp?csem=23&po=8
How many chromosomes are present in each daughter cell after mitosis in a human cell starting with 46 chromosomes?
92
46
23
0
Mitosis produces two daughter cells genetically identical to the parent, each retaining the original diploid chromosome number of 46. This ensures continuity of genetic information. This mechanism prevents the genome from doubling or halving during somatic cell divisions. https://www.biologyonline.com/dictionary/mitosis
What is the primary function of the spindle assembly checkpoint?
Checks DNA replication completeness
Activates replication origins for S phase
Prevents cytokinesis until completion of mitosis
Ensures kinetochores are properly attached to spindle fibers before anaphase
The spindle assembly checkpoint monitors attachment of spindle microtubules to kinetochores, delaying anaphase onset until all chromosomes are bi-oriented. Proper function of this checkpoint prevents aneuploidy. Defects in this checkpoint are implicated in certain cancers. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076802/
How do cyclins and cyclin-dependent kinases regulate the transition from G2 phase to M phase?
Cyclin D binds Cdk4
Cyclin A binds Cdk6
Cyclin B binds Cdk1 to form MPF, triggering mitosis
Cyclin E binds Cdk2
The maturation-promoting factor (MPF) consists of Cyclin B bound to Cdk1 and its activation initiates mitosis. MPF activation is regulated by phosphorylation events that control Cdk1 activity. This coordination ensures that mitosis only begins after DNA integrity and replication are confirmed. https://www.ncbi.nlm.nih.gov/books/NBK21054/
What is the function of cohesin proteins during mitosis?
Split the nuclear envelope
Recruit spindle fibers
Hold sister chromatids together until anaphase
Degrade cyclins
Cohesins form ring-like structures encircling sister chromatids, maintaining their cohesion from S phase until anaphase. By holding sister chromatids together, cohesins facilitate accurate chromosome segregation. Defective cohesion leads to premature chromatid separation and genomic instability. https://www.cell.com/cell/fulltext/S0092-8674(15)00582-8
What molecular mechanism drives contractile ring formation during cytokinesis in animal cells?
Nuclear envelope breakdown
Microtubule polymerization
Actin-myosin ring contraction regulated by RhoA GTPase
Endocytosis of membrane vesicles
Cytokinesis in animal cells involves a contractile ring composed of actin filaments and myosin II motors. Activation of RhoA GTPase at the equatorial cortex triggers formin-mediated actin nucleation. Subsequent myosin II activity generates contractile force to cleave the cell. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC267631/
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Study Outcomes

  1. Understand the phases of the cell cycle -

    Learn to identify and describe each stage in the cell cycle through our cell cycle quiz, from interphase through mitosis to cytokinesis.

  2. Differentiate between mitosis and cytokinesis -

    Clarify the distinctions between nuclear division and cytoplasmic separation to ensure you can accurately identify these critical cell division processes.

  3. Analyze true/false statements on cytokinesis -

    Evaluate statements in our cytokinesis true/false quiz to test your comprehension and debunk common misconceptions about cytokinesis.

  4. Apply your knowledge in multiple-choice questions -

    Use strategic reasoning to answer mitosis quiz and phases of cell cycle quiz multiple-choice questions, reinforcing your understanding of key mitotic events.

  5. Match cell cycle terms with definitions -

    Enhance memory retention by pairing essential terms in this cell division trivia matching exercise with accurate descriptions and functions.

Cheat Sheet

  1. Core Phases of the Cell Cycle -

    The eukaryotic cell cycle follows four main stages - G1 (growth), S (DNA synthesis), G2 (preparation), and M (mitosis and cytokinesis). A handy mnemonic "GPS→M" helps you remember the sequence in any phases of cell cycle quiz. Mastery of these checkpoints lays the foundation for deeper cell biology questions.

  2. Mitosis Stages (PMAT) -

    Mitosis is divided into Prophase, Metaphase, Anaphase, and Telophase - a sequence you can memorize with "Please Make A Taco." In Prophase chromatin condenses, Metaphase aligns chromosomes at the equator, Anaphase separates sister chromatids, and Telophase reforms the nuclear envelope. A strong mitosis quiz score hinges on visualizing these steps in order.

  3. Cytokinesis Mechanics -

    Contrary to a common cytokinesis true/false quiz trap, cytokinesis refers specifically to cytoplasmic division, not nuclear splitting. In animal cells, a contractile ring of actin and myosin pinches the cell, while plant cells build a new cell plate guided by the phragmoplast. Comparing these mechanisms boosts your cell division trivia prowess.

  4. Cell Cycle Checkpoints -

    Three main checkpoints (G1, G2, and M) monitor DNA integrity and proper cell size, using cyclin-CDK complexes such as MPF (Maturation Promoting Factor) to trigger progression. For example, DNA damage halts the cycle at G1 via p53 activation until repair is complete. Understanding these controls is a secret weapon in any cell cycle quiz battle.

  5. DNA Replication Essentials -

    Replication is semiconservative: each new DNA double helix contains one parental and one new strand, as proven by the Meselson - Stahl experiment. Helicase unwinds the helix, DNA polymerase synthesizes the leading strand continuously, and the lagging strand forms Okazaki fragments. Grasping this process ensures success on any cell cycle quiz or cell division trivia challenge.

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