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Quizzes > Quizzes for Business > Healthcare

COVID-19 Knowledge Quiz: Test Your Expertise

Challenge Yourself with Key COVID-19 Questions

Difficulty: Moderate
Questions: 20
Learning OutcomesStudy Material

Welcome to this interactive COVID-19 Knowledge Quiz, designed for students, educators, and health enthusiasts to reinforce key facts and best practices. If you're preparing for the COVID-19 Knowledge Assessment Quiz or want a quick refresher after the General Knowledge and COVID-19 Awareness Quiz, this practice test is perfect. You'll gain confidence in areas like symptom recognition, transmission prevention, and vaccine understanding while enjoying a flexible format you can freely modify in our editor. Feel free to customize questions to match your learning goals and explore more quizzes for further practice.

Which of the following is a common primary symptom of COVID-19?
Skin rash
Hearing loss
Blurred vision
Fever
Fever is one of the most frequently reported primary symptoms of COVID-19. Other options like skin rash or hearing loss are not typical primary symptoms.
What is the primary route of COVID-19 transmission?
Mosquito bites
Respiratory droplets
Contaminated food
Fecal-oral
COVID-19 is primarily spread via respiratory droplets emitted when infected individuals cough, sneeze, or talk. The other routes listed are not major contributors to transmission.
Which public health measure most directly reduces the spread of respiratory droplets during the COVID-19 pandemic?
Surface disinfection
Social media campaigns
Wearing face masks
Frequent handwashing
Wearing face masks directly blocks respiratory droplets at the source, reducing the chance of spread. While handwashing and surface disinfection help with contact transmission, they do not address droplet emission.
Which COVID-19 vaccine is based on mRNA technology?
NVX-CoV2373 (Novavax)
CoronaVac (Sinovac)
Ad26.COV2.S (Johnson & Johnson)
mRNA-1273 (Moderna)
mRNA-1273 (Moderna) is an mRNA vaccine encoding the SARS-CoV-2 spike protein. The others use viral vectors, inactivated virus, or protein subunits.
Which variant is designated as B.1.1.7, first identified in the United Kingdom?
Gamma
Alpha
Beta
Delta
The B.1.1.7 lineage is known as the Alpha variant, first detected in the United Kingdom. Delta, Beta, and Gamma correspond to other lineages.
With an R0 of 3, approximately what percentage of the population must be immune to achieve herd immunity?
67%
75%
50%
33%
The herd immunity threshold is calculated as 1 - 1/R0. For R0 = 3, that equals 1 - 1/3 ≈ 0.67 or 67%.
In a trial, 10 cases per 10,000 person-years occurred in the vaccine group and 100 per 10,000 in placebo. What is the vaccine efficacy?
80%
70%
99%
90%
Vaccine efficacy = 1 - (incidence in vaccine / incidence in placebo) = 1 - (10/100) = 0.90 or 90%.
According to CDC guidelines, what should a fully vaccinated person do after exposure to COVID-19 if they remain asymptomatic?
Immediate isolation for 10 days
Test 3 - 5 days after exposure and wear a mask for 14 days; no quarantine
Quarantine for 14 days with no testing
No action needed
The CDC recommends that fully vaccinated, asymptomatic individuals test 3 - 5 days post-exposure and wear a mask for 14 days, without needing quarantine.
What is the shortest recommended quarantine period for an unvaccinated close contact without symptoms, according to CDC?
14 days with no test
No quarantine required
7 days with a negative test on day 5 or later
10 days with no test
CDC allows ending quarantine after 7 days if a test taken on day 5 or later is negative. A 10-day option without testing is also permissible, but 7 days is the shortest.
Which SARS-CoV-2 variant has been most associated with immune escape due to spike protein mutations?
Delta (B.1.617.2)
Epsilon (B.1.427/B.1.429)
Beta (B.1.351)
Alpha (B.1.1.7)
The Beta variant carries key mutations like E484K that reduce neutralization by antibodies and contribute to immune escape. Other variants have different mutation profiles.
Compared to the original SARS-CoV-2 strain, the Delta variant is characterized by:
Increased transmissibility
Reduced mortality
Lower viral load
Shorter period of infectiousness
The Delta variant is notably more transmissible than the original strain and often leads to higher viral loads. Mortality and infectious period changes are less clear-cut.
Which intervention is most effective at preventing fomite (surface) transmission of COVID-19?
Improved ventilation
Social distancing
Frequent handwashing
Vaccination
Fomite transmission occurs when contaminated surfaces transfer virus to hands. Frequent handwashing removes virus particles and is the most direct preventive measure.
Which vaccination strategy is most effective at reducing COVID-19 mortality in a population with limited doses?
Vaccinating randomly
Prioritizing elderly and high-risk individuals
Vaccinating children first
Vaccinating only healthcare workers
Elderly and high-risk groups face the highest mortality risk, so prioritizing them yields the greatest reduction in deaths when doses are limited.
Which observation from vaccine rollout data best supports the need for booster doses?
No change in antibody levels over time
Vaccine efficacy decreasing from ~95% shortly after vaccination to ~60% after six months
Rise of breakthrough infections to 100%
Initial efficacy below 50% after first dose
A drop in measured vaccine efficacy from around 95% shortly after vaccination to about 60% after six months indicates waning immunity and supports booster dosing.
What characteristic distinguishes a WHO 'variant of concern' (VOC) from a 'variant of interest' (VOI)?
Presence of any mutation in the spike protein
Being identified only in animals
Occurrence in more than 100 countries
Evidence of increased transmissibility, virulence, or decreased effectiveness of interventions
A VOC has demonstrated impacts on transmissibility, disease severity, or countermeasures based on epidemiological or laboratory data. VOIs lack such definitive evidence.
In a population where the basic reproduction number (R0) is 2.5, and 80% of people wear masks that reduce transmission by 50%, what is the effective reproduction number (Re)?
1.0
0.5
1.5
2.0
The effective reproduction number Re = R0 × (1 - compliance × mask efficacy) = 2.5 × (1 - 0.8 × 0.5) = 2.5 × 0.6 = 1.5. This shows reduced but ongoing transmission.
A vaccine shows 95% efficacy against symptomatic COVID-19 but only 40% against asymptomatic infection. What does this suggest about vaccine performance?
It is ineffective at preventing severe disease
It provides sterilizing immunity in most cases
It has no effect on transmission
It is more effective at preventing symptomatic disease than infection
Higher efficacy against symptomatic disease indicates that the vaccine better prevents illness rather than completely blocking infection. Sterilizing immunity would show similar efficacy against asymptomatic cases.
In a community, 30% have immunity from prior infection, and 50% are fully vaccinated with a vaccine that is 90% effective at preventing infection. What is the approximate overall population immunity?
75%
45%
65%
90%
Approximate immunity = prior infection (30%) + vaccination coverage × vaccine efficacy (50% × 90% = 45%), totaling 75%.
A SARS-CoV-2 variant shows a 4-fold reduction in neutralization by sera from vaccinated individuals. What is the likely impact on vaccine effectiveness?
Increase in effectiveness
Complete loss of vaccine protection
Moderate reduction in vaccine effectiveness but continued protection against severe disease
No change in effectiveness
A 4-fold reduction in neutralizing antibody titers usually leads to some drop in vaccine effectiveness, but cell-mediated immunity often maintains protection against severe outcomes.
During a COVID-19 outbreak in a long-term care facility, how often does the CDC recommend testing staff?
Twice weekly
Daily
Weekly
Only if symptomatic
The CDC advises testing all staff at least twice per week during an active outbreak in long-term care to quickly identify and isolate cases. Less frequent testing may miss asymptomatic infections.
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Learning Outcomes

  1. Identify the primary symptoms and transmission routes of COVID-19.
  2. Analyze public health measures and their effectiveness.
  3. Evaluate vaccination strategies and vaccine efficacy data.
  4. Apply CDC guidelines to hypothetical outbreak scenarios.
  5. Demonstrate understanding of variant characteristics and impacts.

Cheat Sheet

  1. Spotting Key COVID-19 Symptoms - Know that fever, cough, and shortness of breath are the classic red flags of COVID-19, while severe chest pain or trouble breathing are urgent warning signs. Tracking these symptoms early helps you act fast and get the care you need. CDC COVID-19 Info
  2. Understanding How COVID-19 Spreads - COVID-19 travels through tiny respiratory droplets when someone coughs, sneezes, or even talks nearby. Wearing a mask creates a barrier that dramatically cuts down on the chances of inhaling or exhaling infectious particles. Time on Mask Mandates
  3. Evaluating Public Health Measures - Social distancing, mask mandates, and vaccination campaigns are powerful tools that work together like a superhero team to slow virus spread. Each measure adds an extra layer of protection - giving communities the best shot at staying healthy. Time on Community Measures
  4. Vaccine Effectiveness Explained - The latest COVID-19 vaccines are about 54% effective at preventing symptomatic cases in adults, reducing not only illness but also the chance of severe outcomes. Even partial protection helps hospitals breathe easier and keeps schools open. AP News Vaccine Report
  5. CDC's Updated Isolation Guidelines - You can end isolation once symptoms improve and you've been fever-free for 24 hours without medication - no more snowy days stuck at home when you feel better! Always follow these steps to protect friends and family. Reuters on CDC Updates
  6. Tracking COVID-19 Variants - Variants like Alpha spread more easily, but vaccines still pack a punch by boosting your immune defenses. Learning how each variant behaves helps you stay one step ahead with the right precautions. Research on Variants
  7. Who Should Get the Latest Vaccines? - The CDC now recommends updated COVID-19 shots for anyone six months and older to target newer variants and maintain strong immunity. Keeping up with these boosters keeps your protection sharp. Reuters on Booster Advice
  8. Understanding Breakthrough Infections - Even vaccinated individuals can catch COVID-19, especially with Omicron and its kin, but the shots still drastically reduce severe illness. Keep masking and distancing when needed to plug any gaps. Time on Breakthroughs
  9. Clinical Guidance for Vaccination - The CDC's detailed guidance covers age-specific schedules and special advice for immunocompromised people, ensuring everyone gets the right dose at the right time. Tailoring vaccination keeps communities safer. CDC Clinical Guidelines
  10. Staying Up to Date on Shots - Regular COVID-19 vaccinations are your best defense against severe illness, hospitalization, and long-term effects. Think of boosters as annual tune-ups that keep your immune system running smoothly. CDC Vaccination Schedule
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