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Quizzes > Quizzes for Business > Healthcare

Chemotherapy Protocol Knowledge Test Challenge

Evaluate Your Oncology Chemotherapy Protocol Mastery Today

Difficulty: Moderate
Questions: 20
Learning OutcomesStudy Material
Colorful paper art depicting a trivia quiz on Chemotherapy Protocol Knowledge Test

Ready to sharpen your understanding of chemotherapy protocols? This Chemotherapy Protocol Knowledge Test offers an engaging oncology quiz with real-world scenarios designed for nursing students and clinicians. You'll explore dosing schedules, safety precautions, and regimen selection while enjoying a free, customizable format that can be tweaked in our editor. Come back to broaden your skills with the EMS Protocol Knowledge Assessment or dive into emergency care with the Hospital ED Protocol Quiz . Don't forget to browse more quizzes for comprehensive practice across disciplines.

Which of the following best describes a standard weekly dosing schedule for paclitaxel in oncology?
175 mg/m^2 IV every 3 weeks
80 mg/m^2 IV weekly
50 mg/m^2 orally daily
6 mg/m^2 continuous infusion
Paclitaxel is commonly administered at 80 mg/m^2 intravenously on a weekly schedule. The 175 mg/m^2 dose is given every three weeks and oral or continuous infusion regimens are not standard.
Which personal protective equipment is essential when preparing cytotoxic chemotherapy agents?
Nitrile chemotherapy-resistant gloves
Cotton laboratory gloves
Leather work gloves
Non-sterile surgical gloves
Nitrile chemotherapy-resistant gloves provide protection against permeability of cytotoxic agents. Ordinary cotton or surgical gloves do not offer sufficient barrier protection.
Which organ-specific toxicity is most closely associated with cumulative dosing of doxorubicin?
Cardiotoxicity
Nephrotoxicity
Neurotoxicity
Hepatotoxicity
Doxorubicin is known for dose-dependent cardiotoxicity manifesting as cardiomyopathy. Other organ toxicities are less characteristic of its cumulative dosing profile.
Concurrent use of fluorouracil and which of the following drugs significantly increases bleeding risk?
Warfarin
Allopurinol
Phenytoin
Leucovorin
Fluorouracil can potentiate the anticoagulant effects of warfarin, leading to elevated INR and increased bleeding risk. Allopurinol and phenytoin are not commonly associated with this interaction, and leucovorin enhances fluorouracil's efficacy.
Which term refers to the highest dose of a chemotherapy agent that does not cause unacceptable side effects?
MTD
LD50
ED50
AUC
The maximum tolerated dose (MTD) is the highest dose patients can receive without severe toxicity. LD50 and ED50 refer to lethal and effective doses, while AUC measures drug exposure over time.
Using the Mosteller formula, what is the approximate body surface area (BSA) for a patient weighing 70 kg and 170 cm tall?
1.8 m^2
1.2 m^2
2.0 m^2
1.4 m^2
The Mosteller formula calculates BSA as sqrt((height(cm)×weight(kg))/3600). For 170 cm and 70 kg, the result is approximately 1.8 m^2.
A patient with a creatinine clearance of 25 mL/min requires cisplatin therapy. Which adjustment is most appropriate?
Hold cisplatin therapy
Reduce dose by 50%
Increase hydration and maintain full dose
Switch to oral formulation
Cisplatin is contraindicated or should be held when creatinine clearance falls below 30 mL/min due to nephrotoxicity risk. Dose reductions or oral switching are not standard under severe renal impairment.
Which of the following describes the most common interaction between capecitabine and warfarin?
Increased INR and bleeding risk
Reduced capecitabine efficacy
Increased thrombosis risk
No significant interaction
Capecitabine inhibits warfarin metabolism, raising INR levels and bleeding risk. No evidence suggests capecitabine reduces warfarin effect or thrombosis risk.
In the event of a small spill of cytotoxic drug powder in the preparation area, what is the first step?
Don appropriate PPE and contain the spill
Wipe with dry paper towels
Vacuum the area
Ignore and continue working
The first step is to don proper personal protective equipment and contain the spill to prevent aerosolization. Dry wiping or vacuuming can increase exposure risk.
Which patient-specific factor most commonly influences chemotherapy dose selection?
Hepatic function
Eye color
Blood type
Height without weight
Hepatic function affects drug metabolism and clearance, making it critical for dose adjustments. Factors like eye color or blood type do not influence dosing.
Leucovorin is co-administered with 5-fluorouracil primarily to:
Enhance binding of 5-FU to thymidylate synthase
Reduce gastrointestinal toxicity
Increase renal clearance
Prevent myelosuppression
Leucovorin stabilizes the 5-FU - thymidylate synthase complex, increasing antitumor activity. It does not reduce GI toxicity or alter renal clearance directly.
Methotrexate is contraindicated in patients with which condition?
Severe renal impairment
Hyperlipidemia
Controlled hypertension
Type 2 diabetes
Methotrexate elimination is renal, so severe renal impairment increases toxicity risk. Other listed conditions do not specifically contraindicate its use.
In carboplatin dosing, the term 'AUC' refers to:
Drug exposure over time
Peak plasma concentration
Volume of distribution
Elimination half-life
Area under the curve (AUC) quantifies total drug exposure over time and is used to calculate carboplatin dosing. It does not directly describe peak concentration or distribution volume.
Which chemotherapy agent is most commonly associated with hand-foot syndrome?
5-fluorouracil
Paclitaxel
Cyclophosphamide
Doxorubicin
5-fluorouracil frequently causes palmar-plantar erythrodysesthesia (hand-foot syndrome). The other agents have distinct toxicity profiles.
The 'nadir' period in chemotherapy refers to:
The lowest blood cell count after treatment
The highest fever after infusion
The initial infusion period
Time of maximum drug concentration
Nadir is the point when blood cell counts, especially neutrophils, reach their lowest after chemotherapy. It is not related to fever or concentration peaks.
Patients homozygous for UGT1A1*28 polymorphism are at increased risk of toxicity when treated with:
Irinotecan
Bleomycin
Vincristine
Busulfan
UGT1A1*28 reduces glucuronidation of SN-38, irinotecan's active metabolite, increasing toxicity risk. This polymorphism is not relevant to the other agents.
In the CHOP chemotherapy regimen for lymphoma, cyclophosphamide is dosed at:
750 mg/m^2 IV on day 1 of a 21-day cycle
600 mg/m^2 IV on days 1 - 3
300 mg/m^2 IV weekly
50 mg/m^2 continuous infusion
CHOP uses cyclophosphamide 750 mg/m^2 IV on day 1 of each 21-day cycle. Other schedules do not correspond to standard CHOP protocol.
What is the primary mechanism of action of bleomycin?
Induction of DNA strand breaks via free radical formation
Microtubule stabilization
Inhibition of dihydrofolate reductase
Topoisomerase II inhibition
Bleomycin generates free radicals that cause single- and double-stranded DNA breaks. It does not affect microtubules, folate metabolism, or topoisomerase II.
Co-administration of paroxetine, a CYP2D6 inhibitor, with tamoxifen leads to:
Reduced formation of active metabolites and decreased tamoxifen efficacy
Increased tamoxifen side effects
Enhanced tamoxifen metabolism
No significant effect
Paroxetine inhibits CYP2D6, reducing conversion of tamoxifen to its active metabolites, which can lower therapeutic efficacy. It does not enhance metabolism.
Which organization sets the recommended guidelines for allowable airborne contamination levels of cytotoxic agents in pharmacy areas?
National Institute for Occupational Safety and Health (NIOSH)
Food and Drug Administration (FDA)
Environmental Protection Agency (EPA)
United States Pharmacopeia Chapter <797>
NIOSH issues guidelines on airborne cytotoxic drug contamination to protect healthcare workers. USP <797> covers sterile compounding standards, not specific contamination thresholds.
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Learning Outcomes

  1. Assess accurate dosing and scheduling of chemotherapy protocols
  2. Identify common drug interactions in oncology regimens
  3. Apply safety procedures for handling cytotoxic agents
  4. Evaluate patient-specific factors influencing protocol selection
  5. Demonstrate contraindication awareness and precaution measures
  6. Master terminology used in standard chemotherapy guidelines

Cheat Sheet

  1. Accurate Dosing & Scheduling - Mastering the math of chemotherapy helps you strike the perfect balance between maximum treatment punch and minimal side effects. Dive into standard dosing formulas and discover how timing tweaks can supercharge efficacy. Chemotherapy to Treat Cancer
  2. Spotting Drug Interactions - Become a detective for oncology drug cross-talk: some meds can boost toxicity or dull chemo's impact. Learn to identify sneaky interactions and adapt regimens like a pro. Safe Handling of Cytotoxics: Guideline Recommendations
  3. Safety with Cytotoxic Agents - Suit up in PPE - gloves, gowns, and face shields - and follow airtight protocols to shield yourself and your team from hazardous exposures. Consistency is key to keeping everyone safe and sound. Hazardous Drugs: Controlling Occupational Exposure
  4. Tailoring to the Patient - No two patients are the same! Factor in age, organ health, and comorbidities to craft personalized chemo plans that boost success rates and slash side effects. Chemotherapy to Treat Cancer
  5. Contraindications & Precautions - Learn which conditions rule out certain chemo drugs and what precautionary steps keep patients safe. A thorough history dive prevents nasty surprises mid-treatment. Safe Handling of Cytotoxics: Guideline Recommendations
  6. Chemo Terminology Mastery - Get fluent in "adjuvant," "neoadjuvant," and "palliative" to decode treatment plans without missing a beat. Clear communication leads to better teamwork and patient care. Chemotherapy to Treat Cancer
  7. Disposal of Cytotoxic Waste - Protect the planet and the people around you by following precise waste-management protocols for chemo leftovers. Correct disposal prevents contamination and keeps labs in green-light status. Hazardous Drugs: Controlling Occupational Exposure
  8. Supportive Care Strategies - From nausea busters to neutropenia guards, tailor support measures that help patients power through treatment days. Good supportive care boosts comfort and adherence. Chemotherapy to Treat Cancer
  9. Recognizing Extravasation - Spotting signs of chemo leaks fast is crucial to stop tissue damage in its tracks. Learn the immediate lifesaving steps to protect patients' skin and health. Safe Handling of Cytotoxics: Guideline Recommendations
  10. Staying Up-to-Date - Oncology protocols evolve fast - make lifelong learning your mantra. Stay current on breakthroughs and guidelines to give patients the safest, most effective care. Safe Handling of Cytotoxics: Guideline Recommendations
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