Fourteen questions on UVA photochemotherapy
UVA photochemotherapy
Created 2019.
This exercise will ask you a set of fourteen questions on UVA photochemotherapy. Each question contains only one correct answer.
If you want to read up on it, you can do so by clicking on the link below.
Learning Objectives
- Describe a fluorescent low-pressure mercury type of PUVA unit
- Outline UVA1 treatment
- List the indications for PUVA
- Outline the pharmacology of 8-methoxypsoralen
- Describe mechanism of action of PUVA on skin diseases
- List safety measures for PUVA
- Describe how to measure minimal phototoxic dose
- Describe dose regimen for oral PUVA
- Describe dose changes if PUVA results in erythema
- Describe dose changes if PUVA treatment is interrupted
- List supplementary treatment that can be used for psoriasis and atopic dermatitis
- List complications of PUVA
- Describe topical PUVA
Editor: Adjunct A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand
UVA photochemotherapy
Created 2019.
This exercise will ask you a set of fourteen questions on UVA photochemotherapy. Each question contains only one correct answer.
If you want to read up on it, you can do so by clicking on the link below.
Learning Objectives
- Describe a fluorescent low-pressure mercury type of PUVA unit
- Outline UVA1 treatment
- List the indications for PUVA
- Outline the pharmacology of 8-methoxypsoralen
- Describe mechanism of action of PUVA on skin diseases
- List safety measures for PUVA
- Describe how to measure minimal phototoxic dose
- Describe dose regimen for oral PUVA
- Describe dose changes if PUVA results in erythema
- Describe dose changes if PUVA treatment is interrupted
- List supplementary treatment that can be used for psoriasis and atopic dermatitis
- List complications of PUVA
- Describe topical PUVA
Editor: Adjunct A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand
1. The electromagnetic radiation waveband known as Ultraviolet-A (UVA) is:
a. 290–320 nm
b. 290–360 nm
c. 340–390 nm
d. 320–400 nm
2. Which of the following treatments is not known as photochemotherapy:
a. The combination of topical tripsoralen and sunlight
b. UVB treatment in patients undergoing chemotherapy
c. The combination of oral 5-methoxypsoralen and UVA
d. The combination of oral 8-methoxypsoralen and UVB
3. Fluorescent UVA bulbs:
a. Produce a fixed radiance
b. Are available in whole body cabinets combined with UVC
c. Have black identification markings
d. Are 8-foot long for hand and foot treatment
4. UVA1:
a. Effective for atopic dermatitis
b. Treatment should be continued once a week for 6 months
c. The waveband of electromagnetic radiation ranging from 310–420 nm
d. The waveband of electromagnetic radiation ranging from 320–360 nm
5. PUVA may be preferred to UVB for:
a. Severe and acute skin conditions
b. Young children
c. Mild, thin plaque psoriasis
d. Hand eczema
6. Which of the following types of psoralen is not used for photochemotherapy:
a. 3-methoxypsoralen
b. Trioxsalen
c. Methoxsalen
d. Bergapten
7. Peak serum levels of oral methoxsalen:
a. Are independent of food intake
b. Vary 2-fold between patients
c. May result in higher levels of theophylline
d. May be lower in patients on steroids
8. For PUVA:
a. The usual dose of methoxsalen is 1.2 mg/kg/day
b. Psoralen interacts maximally with UV at 360 nm
c. Peak erythema occurs 12 hours after PUVA
d. Erythema from PUVA lasts days to weeks
9. Regarding PUVA:
a. A tan promotes the therapeutic effects of UVA
b. Patients should try to get out in the sun between treatments
c. Minimal phototoxic dose (MPD) is measured to decide the first dose of UVA
d. MPD is read 24 hours after exposure
10. For PUVA, starting dose for UVA:
a. Should be 5 J/cm2 for all patients
b. 2–3 J/cm2 is suitable for skin type 3
c. Should be higher for obese patients.
d. Should aim for slight erythema
11. Erythema following PUVA:
a. Treatment is stopped if localized erythema develops
b. Treatment can continue according to schedule if erythema is generalised
c. Settles quickly with cool compresses
d. Erythema is less likely with 2x weekly treatments than 3x weekly treatments
12. Psoriasis treated by PUVA:
a. Clears in 15 treatments in 95% of patients
b. Additional emollients reduce the number of treatments required to clear
c. Often requires an additional 75% dose of UVA to the lower legs
d. Should not be treated with additional acitretin
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