Pharmacology

N- Acetyl cystein is administered preoperatively to a patient planned for CABG, for

a) renal protection

b) bronchodilatation

c) better platelet aggregation

d) improve hemoglobin

Which is the ideal mode of delivering Adenosine for myocardial protection during OHS?

a) add to cold blood cardioplegia in BCP chamber

b) through crystalloid cardioplegia

c) root injection, after cross clamp prior to delivering cardioplegia

d) add to the blood prime in the reservoir

Patients for CABG are on allopurinol 1-2 days prior to surgery, for

a) free radical scavenging

b) inducing diuresis

c) improving coagulation profile

d) coronary vasodilatation

Which of the following statements about ‘heparin resistance’ is FALSE? Heparin Resistance

a) is defined as ACT is < 480sec after 3mg/kg dose of heparin during OHS

b) is seen only if patient is on heparin for a minimum of 7days

c) can be seen in patients on IABP

d) can be due to insufficient antithrombin III

Which of the following statements about Heparin is FALSE?

a) heparin is a mixture of mucopolysaccharides with molecular weight > 10000 Daltons

b) heparin carries a strong positive charge and is the strongest base in the body

c) heparin is found in mast cells , lung and mucosa

d) heparin activates plasma antithrombin III

Most common adverse effect with Hydroxyethyl starch is

a) cerebral edema

b) renal dysfunction

c) thyroid dysfunction

d) pulmonary dysfunction

Which of the following statements about of ‘Gelatins’ is FALSE?

a) gelatin is a large molecular weight protein formed from hydrolysis of collagen

b) sodium content is same as in 0.45% NaCl

c) colloidal osmotic pressure is equal to plasma colloidal osmotic pressure

d) eliminated rapidly via kidney

Which of the following statements about Protamine is FALSE?

a) it has a very short half life

b) it is found in sperm of fish

c) it is electronegative

d) protamine-heparin complex causes hypotension by various mechanisms

Protamine neutralises action of heparin because

a) it is acidic

b) it converts heparin to proheparin

c) it is positive charged

d) it splits heparin to hemiparin & proparin

Abciximab is an antiplatelet agent and acts by

a) potentiating the action of aspirin

b) inhibition of platelet glycoprotein receptor

c) decreasing platelet sensitivity to ADP

d) blocking release of 5HT

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Pharmacology