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Seven questions on photodynamic therapy

Photodynamic therapy
Created 2019.
This exercise will ask you a set of seven questions on photodynamic therapy. Each question contains only one correct answer. 
 
If you want to read up on it, you can do so by clicking on the link below.
 
 

Learning objectives

  • Describe photodynamic therapy (PDT)
  • List current indications for PDT
  • List contraindications to PDT
  • Name two photosensitisers used in topical PDT
  • Describe the mechanism of action
  • Describe the method of treatment for topical PDT
  • Describe side effects of topical PDT
  • Describe the results of PDT for:
      • Actinic keratoses
      • In-situ squamous cell carcinoma
      • Superficial basal cell carcinoma
Created by: Dr Muhammad Wasay Ali Khan, DermNet NZ Volunteer
Editor: Adjunct A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand
Photodynamic therapy
Created 2019.
This exercise will ask you a set of seven questions on photodynamic therapy. Each question contains only one correct answer. 
 
If you want to read up on it, you can do so by clicking on the link below.
 
 

Learning objectives

  • Describe photodynamic therapy (PDT)
  • List current indications for PDT
  • List contraindications to PDT
  • Name two photosensitisers used in topical PDT
  • Describe the mechanism of action
  • Describe the method of treatment for topical PDT
  • Describe side effects of topical PDT
  • Describe the results of PDT for:
      • Actinic keratoses
      • In-situ squamous cell carcinoma
      • Superficial basal cell carcinoma
Created by: Dr Muhammad Wasay Ali Khan, DermNet NZ Volunteer
Editor: Adjunct A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand
1. Photodynamic therapy (PDT):
a. Involves use of a photosensitiser given by intravenous injection or orally
b. Is an oxygen-dependent reaction
c. Requires exposure to UVA
d. May cause skin cancer
2. Current indications for PDT include:
a. Superficial spreading melanoma
b. Superficial basal cell carcinoma
c. Invasive squamous cell carcinoma
d. Seborrhoeic keratoses
3. PDT must not be used for:
a. Actinic cheilitis
b. Superficial basal cell carcinoma
c. Porphyria cutanea tarda
d. In-situ squamous cell carcinoma (Bowen disease)
4. For topical aminolaevulinic acid (ALA) PDT:
a. The active photosensitiser is methyl-ALA
b. The active photosensitiser is protoporphyrin IX
c. ALA penetrates up to 10 mm into the skin
d. It is more effective if the lesion surface is intact
5. Choose the single most active waveband for ALA PDT:
a. 400
b. 500
c. 600
d. 700
6. PDT for basal cell carcinoma (BCC):
a. Three exposures at weekly intervals are recommended
b. The bulk of nodular BCC should be surgically removed prior to PDT
c. Is not suitable for recurrent lesions
d. Cannot be used on the nose
7. Side effects of topical PDT include:
a. Nausea and vomiting
b. A porphyric crisis
c. Generalised photosensitivity
d. Hyperpigmentation
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